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This is the C2 domain-like domain, in greek key form, of thePTEN protein, phosphatidyl-inositol triphosphate phosphatase, and it is the C-terminus. This domain may well include a CBR3 loop which means it plays a central role in membrane binding. This domain associates across an extensive interface with the N-terminal phosphatase domain DSPc (Pfam:PF00782) suggesting that the C2 domain productively positions the catalytic part of the protein onto the membrane [1].
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