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family:comment |
The members of this family are eukaryotic proteins, and includeall three isoforms of the prolyl 4-hydroxylase alpha subunit. This enzyme (EC:1.14.11.2) is important in the post-translational modification of collagen, as it catalyses the formation of 4-hydroxyproline. In vertebrates, the complete enzyme is an alpha2-beta2 tetramer; the beta-subunit is identical to protein disulphide isomerase [1-4]. The function of the N-terminal region featured in this family does not seem to be known.
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