Linked Life Data

PF05902.8

Source:http://linkedlifedata.com/resource/pfam/family/PF05902.8

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
family:comment
At the C-terminus of all known 4.1 proteins is a sequence domainunique to these proteins, known as the C-terminal domain (CTD). Mammalian CTDs are associated with a growing number of protein-protein interactions, although such activities have yet to be associated with invertebrate CTDs. Mammalian CTDs are generally defined by sequence alignment as encoded by exons 18-21. Comparison of known vertebrate 4.1 proteins with invertebrate 4.1 proteins indicates that mammalian 4.1 exon 19 represents a vertebrate adaptation that extends the sequence of the CTD with a Ser/Thr-rich sequence. The CTD was first described as a 22/24-kDa domain by chymotryptic digestion of erythrocyte 4.1 (4.1R). CTD is thought to represent an independent folding structure which has gained function since the divergence of vertebrates from invertebrates [1].
family:id
4_1_CTD
family:description
4.1 protein C-terminal domain (CTD)
family:authorList
Moxon SJ
family:familyType
Domain
family:dbReference
family:pubmed
family:protein