Linked Life Data

PF05835.7

Source:http://linkedlifedata.com/resource/pfam/family/PF05835.7

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
family:comment
This family consists of several eukaryotic synaphin 1 and 2proteins. Synaphin/complexin is a cytosolic protein that preferentially binds to syntaxin within the SNARE complex. Synaphin promotes SNAREs to form precomplexes that oligomerise into higher order structures. A peptide from the central, syntaxin binding domain of synaphin competitively inhibits these two proteins from interacting and prevents SNARE complexes from oligomerising. It is thought that oligomerisation of SNARE complexes into a higher order structure creates a SNARE scaffold for efficient, regulated fusion of synaptic vesicles [1]. Synaphin promotes neuronal exocytosis by promoting interaction between the complementary syntaxin and synaptobrevin transmembrane regions that reside in opposing membranes prior to fusion [2].
family:id
Synaphin
family:description
Synaphin protein
family:authorList
Moxon SJ
family:familyType
Family
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family:pubmed
family:protein