Linked Life Data

PF05716.8

Source:http://linkedlifedata.com/resource/pfam/family/PF05716.8

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
family:comment
This family consists of several mammalian protein kinase Aanchoring protein 3 (PRKA3) or A-kinase anchor protein 110 kDa (AKAP 110) sequences. Agents that increase intracellular cAMP are potent stimulators of sperm motility. Anchoring inhibitor peptides, designed to disrupt the interaction of the cAMP-dependent protein kinase A (PKA) with A kinase-anchoring proteins (AKAPs), are potent inhibitors of sperm motility. PKA anchoring is a key biochemical mechanism controlling motility. AKAP110 shares compartments with both RI and RII isoforms of PKA and may function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction [1].
family:id
AKAP_110
family:description
A-kinase anchor protein 110 kDa (AKAP 110)
family:authorList
Moxon SJ
family:familyType
Family
family:dbReference
family:pubmed
family:protein