Source:http://linkedlifedata.com/resource/pfam/family/PF02762.9
| Predicate | Object |
|---|---|
| rdf:type | |
| family:comment |
Cbl is an adaptor protein that binds EGF receptors (or othertyrosine kinases) and SH3 domains, functioning as a negative regulator of many signaling pathways. The N-terminal domain is evolutionarily conserved, and is known to bind to phosphorylated tyrosine residues. The so called N-terminal domain is actually 3 structural domains, of which this is the C-terminal SH2 domain.
|
| family:id |
Cbl_N3
|
| family:description |
CBL proto-oncogene N-terminus, SH2-like domain
|
| family:authorList |
Bateman A, Mian N, Griffiths-Jones SR
|
| family:familyType |
Domain
|
| family:dbReference | |
| family:pubmed | |
| family:protein |