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rdf:type |
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family:comment |
The histidine-containing phosphotransfer (HPt) domain is a novelprotein module with an active histidine residue that mediates phosphotransfer reactions in the two-component signaling systems. A multistep phosphorelay involving the HPt domain has been suggested for these signaling pathways. The crystal structure of the HPt domain of the anaerobic sensor kinase ArcB has been determined [1]. The domain consists of six alpha helices containing a four-helix bundle-folding. The pattern of sequence similarity of the HPt domains of ArcB and components in other signaling systems can be interpreted in light of the three-dimensional structure and supports the conclusion that the HPt domains have a common structural motif both in prokaryotes and eukaryotes. In S. cerevisiae ypd1p this domain has been shown to contain a binding surface for Ssk1p (response regulator receiver domain containing protein Pfam:PF00072) [2].
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family:id |
Hpt
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family:description |
Hpt domain
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family:authorList |
Bateman A
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family:familyType |
Family
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family:dbReference |
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family:pubmed |
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family:protein |
http://linkedlifedata.com/resource/pfam/protein/CHEA_THEMA,
http://linkedlifedata.com/resource/pfam/protein/Q8KLS0_RHOSH,
http://linkedlifedata.com/resource/pfam/protein/Q9SLX1_MAIZE,
http://linkedlifedata.com/resource/pfam/protein/YPD1_YEAST,
http://linkedlifedata.com/resource/pfam/protein/Q7NXK5_CHRVO,
http://linkedlifedata.com/resource/pfam/protein/Q8YQQ8_NOSS1,
http://linkedlifedata.com/resource/pfam/protein/Q9AAK3_CAUCR,
http://linkedlifedata.com/resource/pfam/protein/Q89T58_BRAJA,
http://linkedlifedata.com/resource/pfam/protein/Q8VL11_AZOBR,
http://linkedlifedata.com/resource/pfam/protein/P72250_RHOCE,
http://linkedlifedata.com/resource/pfam/protein/Q8DK49_THEEB,
http://linkedlifedata.com/resource/pfam/protein/P73172_SYNY3,
http://linkedlifedata.com/resource/pfam/protein/Q55443_SYNY3,
http://linkedlifedata.com/resource/pfam/protein/Q8YXY8_NOSS1,
http://linkedlifedata.com/resource/pfam/protein/Q8DLX7_THEEB,
http://linkedlifedata.com/resource/pfam/protein/Q8YYC4_NOSS1,
http://linkedlifedata.com/resource/pfam/protein/Q8YV20_NOSS1,
http://linkedlifedata.com/resource/pfam/protein/FRZE_MYXXA,
http://linkedlifedata.com/resource/pfam/protein/Q7X4X3_RHOCE,
http://linkedlifedata.com/resource/pfam/protein/Q8VR14_MYXXA,
http://linkedlifedata.com/resource/pfam/protein/Q92YM5_RHIME,
http://linkedlifedata.com/resource/pfam/protein/Q8KQ60_MYXXA,
http://linkedlifedata.com/resource/pfam/protein/Q82V52_NITEU,
http://linkedlifedata.com/resource/pfam/protein/Q8Y1L8_RALSO,
http://linkedlifedata.com/resource/pfam/protein/Q8P6P6_XANCP,
http://linkedlifedata.com/resource/pfam/protein/Q87D38_XYLFT,
http://linkedlifedata.com/resource/pfam/protein/Q87VA9_PSESM,
http://linkedlifedata.com/resource/pfam/protein/Q88D40_PSEPK,
http://linkedlifedata.com/resource/pfam/protein/O87001_PSEAE,
http://linkedlifedata.com/resource/pfam/protein/Q98PD0_RHILO,
http://linkedlifedata.com/resource/pfam/protein/O58222_PYRHO,
http://linkedlifedata.com/resource/pfam/protein/Q8PX97_METMA,
http://linkedlifedata.com/resource/pfam/protein/Q8Q010_METMA,
http://linkedlifedata.com/resource/pfam/protein/O29222_ARCFU,
http://linkedlifedata.com/resource/pfam/protein/Q8RA13_THETN,
http://linkedlifedata.com/resource/pfam/protein/Q893S8_CLOTE,
http://linkedlifedata.com/resource/pfam/protein/Q97GZ5_CLOAB,
http://linkedlifedata.com/resource/pfam/protein/Q9K8N5_BACHD,
http://linkedlifedata.com/resource/pfam/protein/CHEA_BACSU,
http://linkedlifedata.com/resource/pfam/protein/O25153_HELPY,
http://linkedlifedata.com/resource/pfam/protein/CHEA_BORBU,
http://linkedlifedata.com/resource/pfam/protein/O85747_TREDE,
http://linkedlifedata.com/resource/pfam/protein/CHEA_TREPA,
http://linkedlifedata.com/resource/pfam/protein/Q9KKK9_VIBCH,
http://linkedlifedata.com/resource/pfam/protein/Q97MS3_CLOAB,
http://linkedlifedata.com/resource/pfam/protein/O87714_CAUCR,
http://linkedlifedata.com/resource/pfam/protein/O85126_RHIRD,
http://linkedlifedata.com/resource/pfam/protein/CHEA_RHOSH,
http://linkedlifedata.com/resource/pfam/protein/Q8XQ78_RALSO,
http://linkedlifedata.com/resource/pfam/protein/Q7VZ97_BORPE,
http://linkedlifedata.com/resource/pfam/protein/Q9I6V4_PSEAE,
http://linkedlifedata.com/resource/pfam/protein/Q8EF66_SHEON,
http://linkedlifedata.com/resource/pfam/protein/Q8F6Q0_LEPIN,
http://linkedlifedata.com/resource/pfam/protein/Q8F3H8_LEPIN,
http://linkedlifedata.com/resource/pfam/protein/Q7NV36_CHRVO,
http://linkedlifedata.com/resource/pfam/protein/Q7NZA8_CHRVO,
http://linkedlifedata.com/resource/pfam/protein/Q888V3_PSESM,
http://linkedlifedata.com/resource/pfam/protein/Q8P7B1_XANCP,
http://linkedlifedata.com/resource/pfam/protein/O51515_BORBU,
http://linkedlifedata.com/resource/pfam/protein/O33554_RHOSH,
http://linkedlifedata.com/resource/pfam/protein/Q9KS63_VIBCH,
http://linkedlifedata.com/resource/pfam/protein/Q7NSH6_CHRVO,
http://linkedlifedata.com/resource/pfam/protein/Q8P9G2_XANCP,
http://linkedlifedata.com/resource/pfam/protein/O52261_PSEPU,
http://linkedlifedata.com/resource/pfam/protein/Q8ECD6_SHEON,
http://linkedlifedata.com/resource/pfam/protein/Q8DB68_VIBVU,
http://linkedlifedata.com/resource/pfam/protein/CHEA_ECOLI,
http://linkedlifedata.com/resource/pfam/protein/Q8GMB7_SERPL,
http://linkedlifedata.com/resource/pfam/protein/Q7N840_PHOLL,
http://linkedlifedata.com/resource/pfam/protein/O08235_PECCC,
http://linkedlifedata.com/resource/pfam/protein/Q8DC68_VIBVU,
http://linkedlifedata.com/resource/pfam/protein/Q8YUC4_NOSS1,
http://linkedlifedata.com/resource/pfam/protein/P73035_SYNY3,
http://linkedlifedata.com/resource/pfam/protein/Q8YT51_NOSS1,
http://linkedlifedata.com/resource/pfam/protein/Q8YUQ6_NOSS1,
http://linkedlifedata.com/resource/pfam/protein/BARA_ECOLI,
http://linkedlifedata.com/resource/pfam/protein/TORS_ECOLI,
http://linkedlifedata.com/resource/pfam/protein/O31138_PSEAE,
http://linkedlifedata.com/resource/pfam/protein/GACS_PSESY,
http://linkedlifedata.com/resource/pfam/protein/O68317_VIBCH,
http://linkedlifedata.com/resource/pfam/protein/P73828_SYNY3,
http://linkedlifedata.com/resource/pfam/protein/P73926_SYNY3,
http://linkedlifedata.com/resource/pfam/protein/RPFC_XANCP,
http://linkedlifedata.com/resource/pfam/protein/ARCB_SHIFL,
http://linkedlifedata.com/resource/pfam/protein/O30740_RHOSH,
http://linkedlifedata.com/resource/pfam/protein/O85661_PROMI,
http://linkedlifedata.com/resource/pfam/protein/Q48297_HALSA,
http://linkedlifedata.com/resource/pfam/protein/CHEA_LISMO,
http://linkedlifedata.com/resource/pfam/protein/BVGS_BORPE,
http://linkedlifedata.com/resource/pfam/protein/Q7NVX8_CHRVO,
http://linkedlifedata.com/resource/pfam/protein/Q8GD29_BORAV,
http://linkedlifedata.com/resource/pfam/protein/Q883N4_PSESM
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