The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method."^^ . . . . . . "Signaling by EGFR"^^ . "Epidermal Growth Factor Receptor (EGFR) signaling"^^ . . . . . . . . . . . . . . . . . . . . . . .