| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
VEGFR-2 binds VEGF-A, -C, -D, and -E homodimers. VEGFR-2 is the primary mediator of the physiological effects of VEGF-A in angiogenesis, including microvascular permeability, endothelial cell proliferation, invasion, migration, and survival. In endothelial cells, these effects are mediated via activation of a phospholipase gamma-protein kinase C-Raf-MAPK signaling pathway for proliferation and PI3K and focal adhesion kinase for survival and migration. VEGFR-2 is the important receptor among VEGFR protiens and its activation and signaling may be positively or negatively regulated by co-expression and activation of various factors and other VEGF receptors like VEGFR-1 (Hicklin and Ellis 2005).The regulatory events of this receptor will be annotated in subsequent modules.
|
| biopax3:xref |
http://identifiers.org/pubmed/11004490,
http://identifiers.org/pubmed/11387210,
http://identifiers.org/pubmed/12881528,
http://identifiers.org/pubmed/1417831,
http://identifiers.org/pubmed/15585754,
http://identifiers.org/pubmed/16336962,
http://identifiers.org/pubmed/16835467,
http://identifiers.org/pubmed/7824266,
http://identifiers.org/pubmed/8617204,
http://identifiers.org/pubmed/9207067,
http://identifiers.org/pubmed/9435229
|
| biopax3:evidenceCode |