| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
Both IRAK1 and IRAK4 were shown to phosphorylate Pellino isoforms in vitro. The phosphorylation of Pellino proteins is a necessary step in enhancing of their E3 ubiquitin ligase activity. It remains unclear whether IRAK1(as shown here), IRAK4, or both protein kinases mediate the activation of Pellino isoforms in vivo.
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| biopax3:xref | |
| biopax3:evidenceCode |