<http://www.reactome.org/biopax/48892BiochemicalReaction3814> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://www.biopax.org/release/biopax-level3.owl#BiochemicalReaction> .
<http://www.reactome.org/biopax/48892BiochemicalReaction3814> <http://www.biopax.org/release/biopax-level3.owl#comment> "Reviewed: D'Eustachio, P, 2011-08-23"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://www.reactome.org/biopax/48892BiochemicalReaction3814> <http://www.biopax.org/release/biopax-level3.owl#comment> "Edited: Jassal, B, 2011-08-17"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://www.reactome.org/biopax/48892BiochemicalReaction3814> <http://www.biopax.org/release/biopax-level3.owl#comment> "Authored: Jassal, B, 2011-08-17"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://www.reactome.org/biopax/48892BiochemicalReaction3814> <http://www.biopax.org/release/biopax-level3.owl#comment> "In the second salvage step, dihydrofolate reductase (DHFR) can regenerate BH4 from BH2, a process which increases the BH4:BH2 ratio providing BH4 for coupled eNOS production of NO. In mice cell lines, DHFR inhibition or knockdown diminishes the BH4:BH2 ratio and exacerbates eNOS uncoupling (Crabtree et al. 2009)."^^<http://www.w3.org/2001/XMLSchema#string> .
<http://www.reactome.org/biopax/48892BiochemicalReaction3814> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:UnificationXref:REACTOME+DATABASE+ID_1497770> .
<http://www.reactome.org/biopax/48892BiochemicalReaction3814> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:UnificationXref:REACTOME_REACT_115762_1> .
<http://www.reactome.org/biopax/48892BiochemicalReaction3814> <http://www.biopax.org/release/biopax-level3.owl#xref> <http://identifiers.org/pubmed/19666465> .
<http://www.reactome.org/biopax/48892BiochemicalReaction3814> <http://www.biopax.org/release/biopax-level3.owl#dataSource> <http://www.reactome.org/biopax/48892Provenance1> .
<http://www.reactome.org/biopax/48892BiochemicalReaction3814> <http://www.biopax.org/release/biopax-level3.owl#dataSource> <urn:biopax:Provenance:reactome_hm_41> .
<http://www.reactome.org/biopax/48892BiochemicalReaction3814> <http://www.biopax.org/release/biopax-level3.owl#displayName> "Salvage - BH2 is reduced to BH4 by Dhfr"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://www.reactome.org/biopax/48892BiochemicalReaction3814> <http://www.biopax.org/release/biopax-level3.owl#eCNumber> "1.5.1.3"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://www.reactome.org/biopax/48892BiochemicalReaction3814> <http://www.biopax.org/release/biopax-level3.owl#left> <http://www.reactome.org/biopax/48892SmallMolecule239> .
<http://www.reactome.org/biopax/48892BiochemicalReaction3814> <http://www.biopax.org/release/biopax-level3.owl#left> <http://www.reactome.org/biopax/48892SmallMolecule635> .
<http://www.reactome.org/biopax/48892BiochemicalReaction3814> <http://www.biopax.org/release/biopax-level3.owl#left> <http://www.reactome.org/biopax/48892SmallMolecule1647> .
<http://www.reactome.org/biopax/48892BiochemicalReaction3814> <http://www.biopax.org/release/biopax-level3.owl#right> <http://www.reactome.org/biopax/48892SmallMolecule692> .
<http://www.reactome.org/biopax/48892BiochemicalReaction3814> <http://www.biopax.org/release/biopax-level3.owl#right> <http://www.reactome.org/biopax/48892SmallMolecule636> .