. "Reviewed: Mohammadi, M, 2007-02-06 21:44:35"^^ . "Authored: de Bono, B, 2007-01-10 10:27:18"^^ . "The ability of growth factors to protect from apoptosis is primarily due to the activation of the AKT survival pathway. P-I-3-kinase dependent activation of PDK leads to the activation of AKT which in turn affects the activity or expression of pro-apoptotic factors, which contribute to protection from apoptosis. AKT activation also blocks the activity of GSK-3b which could lead to additional antiapoptotic signals."^^ . "Edited: Jupe, S, 2010-02-03"^^ . . . . . . . . . . "PI-3K cascade"^^ . . . . . . . . . . . . . . . . .