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| biopax3:comment |
Authored: Jassal, B, 2005-01-10 12:51:46,
NICD translocates to the nucleus and assembles into a ternary complex with the CSL (human RBPJ i.e. CBF1/ fly Suppressor of Hairless/ worm Lag1) DNA-binding protein and the Mastermind co-activator. This complex activates the transcription of downstream gene targets like HES (Hairy/Enhancer of Split) and HES-related (HRT, also named CHF, HEY, HESR, gridlock) genes.
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| biopax3:xref | |
| biopax3:dataSource | |
| biopax3:displayName |
NICD traffics to nucleus
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| biopax3:organism | |
| biopax3:pathwayComponent |
http://www.reactome.org/biopax/48887BiochemicalReaction3314,
http://www.reactome.org/biopax/48887BiochemicalReaction3337,
http://www.reactome.org/biopax/48887BiochemicalReaction3339,
http://www.reactome.org/biopax/48887BiochemicalReaction3341,
http://www.reactome.org/biopax/48887BiochemicalReaction66
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| biopax3:pathwayOrder |