<http://www.reactome.org/biopax/48887BiochemicalReaction74> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://www.biopax.org/release/biopax-level3.owl#BiochemicalReaction> .
<http://www.reactome.org/biopax/48887BiochemicalReaction74> <http://www.biopax.org/release/biopax-level3.owl#comment> "Reviewed: Heldin, CH, 2006-04-18 14:26:12"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://www.reactome.org/biopax/48887BiochemicalReaction74> <http://www.biopax.org/release/biopax-level3.owl#comment> "Reviewed: Huang, Tao, 2012-05-14"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://www.reactome.org/biopax/48887BiochemicalReaction74> <http://www.biopax.org/release/biopax-level3.owl#comment> "Authored: Heldin, CH, Moustakas, A, Huminiecki, L, Jassal, B, 2006-02-02"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://www.reactome.org/biopax/48887BiochemicalReaction74> <http://www.biopax.org/release/biopax-level3.owl#comment> "Edited: Jassal, B, 2006-02-10 14:02:35"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://www.reactome.org/biopax/48887BiochemicalReaction74> <http://www.biopax.org/release/biopax-level3.owl#comment> "The phosphorylated R-SMAD:CO-SMAD complex rapidly translocates to the nucleus (Xu et al. 2000, Kurisaki et al. 2001, Xiao et al. 2003) where it binds directly to DNA and interacts with a plethora of transcription co-factors. Regulation of target gene expression can be either positive or negative. A classic example of a target gene of the pathway are the genes encoding for I-SMADs. Thus, TGF-beta/SMAD signaling induces the expression of the negative regulators of the pathway (negative feedback loop)."^^<http://www.w3.org/2001/XMLSchema#string> .
<http://www.reactome.org/biopax/48887BiochemicalReaction74> <http://www.biopax.org/release/biopax-level3.owl#xref> <http://identifiers.org/pubmed/12592392> .
<http://www.reactome.org/biopax/48887BiochemicalReaction74> <http://www.biopax.org/release/biopax-level3.owl#xref> <http://identifiers.org/pubmed/10934479> .
<http://www.reactome.org/biopax/48887BiochemicalReaction74> <http://www.biopax.org/release/biopax-level3.owl#xref> <http://identifiers.org/pubmed/11294908> .
<http://www.reactome.org/biopax/48887BiochemicalReaction74> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:UnificationXref:REACTOME+DATABASE+ID_173488> .
<http://www.reactome.org/biopax/48887BiochemicalReaction74> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:UnificationXref:REACTOME_REACT_6726_3> .
<http://www.reactome.org/biopax/48887BiochemicalReaction74> <http://www.biopax.org/release/biopax-level3.owl#dataSource> <urn:biopax:Provenance:reactome_hm_41> .
<http://www.reactome.org/biopax/48887BiochemicalReaction74> <http://www.biopax.org/release/biopax-level3.owl#dataSource> <http://www.reactome.org/biopax/48887Provenance1> .
<http://www.reactome.org/biopax/48887BiochemicalReaction74> <http://www.biopax.org/release/biopax-level3.owl#displayName> "The SMAD2/3:SMAD4 complex transfers to the nucleus"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://www.reactome.org/biopax/48887BiochemicalReaction74> <http://www.biopax.org/release/biopax-level3.owl#left> <http://www.reactome.org/biopax/48887Complex140> .
<http://www.reactome.org/biopax/48887BiochemicalReaction74> <http://www.biopax.org/release/biopax-level3.owl#right> <http://www.reactome.org/biopax/48887Complex33> .