Source:http://www.reactome.org/biopax/48887BiochemicalReaction726
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Authored: Williams, MG, 2007-07-11 16:49:12,
Edited: Gillespie, ME, 0000-00-00 00:00:00,
Once the TNF-aplha:TNF-R1:TRADD complex is formed the two TNF-alpha mediated pathways are possible. The variable is the recruitment of FADD to the larger complex formed by the TNF-aplha:TNF-R1 platform via the interaction of the Death Domains. The steps leading to the Jun, NF kappaB, or apoptotic pathways are rife with modulation.,
Reviewed: Silverman, N, Lemaitre, B, 2008-06-20 10:21:55
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TNF:TNF-R1 binds TRADD, TRAF2 and RIP Complex
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