Source:http://www.reactome.org/biopax/48887BiochemicalReaction5179
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Authored: Jassal, B, 2008-05-19 12:57:01,
Edited: Jassal, B, 2008-05-19 12:57:01,
Leukotriene B4 (LTB4) is formed from arachidonic acid and is a potent inflammatory mediator. LTB4's activity is terminated by formation of its omega hydroxylated metabolite, 20-hydroxyleukotriene B4 (20oh-LTB4), catalysed by CYP4F2 primarily in human liver (Jin et al. 1998) and also by CYP4F3 (Kikuta et al. 1998).,
Reviewed: D'Eustachio, P, 2008-05-28 08:30:54
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LTB4 is hydroxylated to 20oh-LTB4 by CYP4F2/4F3
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CYP4F2 omega-hydroxylates leukotriene B4, thus inactivating it
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1.14.13.30
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