Source:http://www.reactome.org/biopax/48887BiochemicalReaction4484
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At the endoplasmic reticulum (ER) membrane, phosphatidylcholine (PC) is hydrolyzed and has one of its acyl chains cleaved off by a phospholipase A2 to form 1-acyl lysophosphatidylcholine (LPC). The phospholipases are either cytosolic phospholipase A2 alpha/beta/delta/zeta (PLA2G4A/B/D/F) (Ghomashchi et al. 2010, Clarke et al. 1991, Sharp et al. 1994, Song et al. 1999, Chiba et al. 2004), 85 kDa calcium-independent phospholipase A2 (PLA2G6) (Larsson et al. 1998, Ma et al. 1999, Larsson Forsell et al. 1999), group XVI phospholipase A2 (PLA2G16) (Duncan et al. 2008), or Phospholipase B-like 1 (PLBD1) (Xu et al. 2009). PLBD1 acts as a phospholipase A2 but in addition has the propensity to hydrolyze the lysophospholipid formed in its initial reaction.,
Authored: Williams, MG, 2011-09-14,
Edited: Williams, MG, 2011-08-12
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| biopax3:xref |
http://identifiers.org/pubmed/10085124,
http://identifiers.org/pubmed/10092647,
http://identifiers.org/pubmed/10336645,
http://identifiers.org/pubmed/10358058,
http://identifiers.org/pubmed/14709560,
http://identifiers.org/pubmed/15944408,
http://identifiers.org/pubmed/18614531,
http://identifiers.org/pubmed/19019078,
http://identifiers.org/pubmed/1904318,
http://identifiers.org/pubmed/19501189,
http://identifiers.org/pubmed/20705608,
http://identifiers.org/pubmed/8083230,
http://identifiers.org/pubmed/9417066,
http://identifiers.org/pubmed/9705332,
urn:biopax:UnificationXref:REACTOME DATABASE ID_1482856,
urn:biopax:UnificationXref:REACTOME_REACT_120953_1
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PC is hydrolyzed to 1-acyl LPC by PLA2[5]
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3.1.1.4
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