Source:http://www.reactome.org/biopax/48887BiochemicalReaction3887
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Authored: Blackburn, EH, Seidel, J, 2006-03-09 19:41:08,
Reviewed: Price, C, 2006-07-13 18:33:38,
The template of hTERC directs the sequential addition of nucleotides to the 3' telomeric DNA end. Following addition of a nucleotide, the template and catalytic site must move relative to one another within the telomerase RNP to place the appropriate template residue in the active site. As base-pairing and nucleotide addition occur at one end of the template, base pair melting occurs at the other (Collins and Greider 1993; Wang and Blackburn, 1997; Hammond and Cech 1998; Benjamin et al. 2000; Forstemann and Lingner 2005). This un-pairing is thought to reduce the energy used for mediating the subsequent translocation step. Nucleotide addition can occur up until the template boundary which in hTERC is defined by a helix called P1b (Chen and Greider 2003).<br>
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| biopax3:xref |
http://identifiers.org/pubmed/10825187,
http://identifiers.org/pubmed/14630939,
http://identifiers.org/pubmed/15189140,
http://identifiers.org/pubmed/15776019,
http://identifiers.org/pubmed/8330740,
http://identifiers.org/pubmed/9049315,
http://identifiers.org/pubmed/9548747,
urn:biopax:RelationshipXref:GENE ONTOLOGY_GO:0007004,
urn:biopax:UnificationXref:REACTOME DATABASE ID_163090,
urn:biopax:UnificationXref:REACTOME_REACT_8019_1
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Elongation Of The Telomeric Chromosome End
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