Source:http://www.reactome.org/biopax/48887BiochemicalReaction3615
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Authored: Geiger, B, Horwitz, R, 2008-05-07 08:30:32,
Edited: Garapati, P V, 2008-03-11 10:20:45,
Reviewed: Yamada, K, Humphries, MJ, Hynes, R, 2008-05-07 08:53:37,
The alpha1/beta1 integrin, also known as very late antigen (VLA)-1, is mostly expressed on smooth muscle cells and are also found on fibroblasts, osteoblasts, chondrocytes, endothelial cells and lymphocytes. They have a specific inserted domain or I domain as a part of their alpha subunit. This I domain is responsible for the recognition and interaction with collagen molecules in the extracellular matrix (ECM). VLA-1 primarily binds to type IV but also to type I collagen. By outside-in transmembranal signaling to the interior of the cell, it mediates adhesion, migration, proliferation, remodeling of the ECM, and cytokine secretion by endothelial cells, mesangial cells, fibroblasts, and immunocytes.
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Interaction of integrin alpha1beta1 with Type IV collagen
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