<http://www.reactome.org/biopax/48887BiochemicalReaction2857> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://www.biopax.org/release/biopax-level3.owl#BiochemicalReaction> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2857> <http://www.biopax.org/release/biopax-level3.owl#comment> "Authored: Ray, KP, 2010-05-17"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2857> <http://www.biopax.org/release/biopax-level3.owl#comment> "Edited: Jupe, S, 2010-08-06"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2857> <http://www.biopax.org/release/biopax-level3.owl#comment> "Reviewed: Lopez, AF, 2010-09-06"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2857> <http://www.biopax.org/release/biopax-level3.owl#comment> "Reviewed: Hercus, TR, 2010-09-06"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2857> <http://www.biopax.org/release/biopax-level3.owl#comment> "The alpha subunit of the IL3 receptor binds IL 3 with low affinity. Binding of this dimer to the common beta subunit (Bc) confers high affinity binding. Recent models of receptor activation suggest a sequential activation that is initiated by the low-affinity interaction of ligand with the alpha chain to form a binary complex. This binary complex is then able to bind preformed Bc dimers generating a 2:2:2 hexameric complex (Hansen et al. 2008). Covalent linkage of the receptor subunits is required for receptor signalling (Stomski et al. 1996)."^^<http://www.w3.org/2001/XMLSchema#string> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2857> <http://www.biopax.org/release/biopax-level3.owl#xref> <http://identifiers.org/pubmed/18692472> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2857> <http://www.biopax.org/release/biopax-level3.owl#xref> <http://identifiers.org/pubmed/8649415> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2857> <http://www.biopax.org/release/biopax-level3.owl#xref> <http://identifiers.org/pubmed/1833064> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2857> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:UnificationXref:REACTOME+DATABASE+ID_450031> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2857> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:UnificationXref:REACTOME_REACT_23772_2> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2857> <http://www.biopax.org/release/biopax-level3.owl#xref> <http://identifiers.org/pubmed/10477686> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2857> <http://www.biopax.org/release/biopax-level3.owl#dataSource> <urn:biopax:Provenance:reactome_hm_41> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2857> <http://www.biopax.org/release/biopax-level3.owl#dataSource> <http://www.reactome.org/biopax/48887Provenance1> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2857> <http://www.biopax.org/release/biopax-level3.owl#displayName> "Interleukin-3 receptor alpha: Interleukin-3 binds IL3RB:JAK2"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2857> <http://www.biopax.org/release/biopax-level3.owl#left> <http://www.reactome.org/biopax/48887Complex3562> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2857> <http://www.biopax.org/release/biopax-level3.owl#left> <http://www.reactome.org/biopax/48887Complex3612> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2857> <http://www.biopax.org/release/biopax-level3.owl#right> <http://www.reactome.org/biopax/48887Complex3615> .