. "Reviewed: D'Eustachio, P, Matthews, L, Gillespie, ME, 2008-12-02 16:25:31"^^ . "Edited: May, B, 2009-06-02 00:51:49"^^ . "Authored: May, B, 2009-06-02 00:51:49"^^ . "Reviewed: Urano, F, 2010-04-30"^^ . "Dimerization of the N-terminal luminal regions of IRE1-alpha brings the cytosolic C-terminal regions in proximity. The C-terminal region possesses kinase activity and the homodimer trans-autophosphorylates. From homology with Saccharomyces IRE1-alpha the phosphorylation of human IRE1-alpha is believed to be at Ser724."^^ . . . . . . . . "Autophosphorylation of IRE1 dimer"^^ . "2.7.11"^^ . . . . . . .