. "Edited: May, B, 2011-01-23"^^ . "Reviewed: Peng, C, 2011-08-24"^^ . "Authored: May, B, 2011-01-23"^^ . "As inferred from the response of the activin receptor to activin, the type II component of the NODAL receptor phosphorylates the type I component in response to NODAL binding. As inferred from mouse and frog (Xenopus) NODAL can signal via the ACVR1C (ALK7) type I activin receptor (Reissman et al. 2001) though this may be dispensable for development in mouse (Jornvall et al. 2004)."^^ . . . . . . . . . "Type II Activin Receptor (ActRIIB/ACVR2B) Phosphorylates Type I Activin Receptor (ActRIC/ACVR1C) in Response to NODAL"^^ . "2.7.11"^^ . . . . . . .