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biopax3:comment |
MODEL_NOTES=Panther Pathway: P00035 The interferon-gamma signaling pathway modulates the antiproliferative and antiviral properties of interferon-gamma. Signal transduction from the membrane to the nucleus is rapid and direct. The main signaling pathway involves the activation of STAT1 by the Jak family of tyrosine kinases at the cell membrane, followed by release, dimerization, and translocation of STAT1 to the nucleus, where they transcriptional induce expression of many gene products. Medline=11929133 Medline=14525967 PMID: 11929133 PMID: 14525967
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