Catalysis of the reaction: protein glutamine + alkylamine = protein N5-alkylglutamine + NH3. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links.
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Catalysis of the reaction: protein glutamine + alkylamine = protein N5-alkylglutamine + NH3. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links.
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R-glutaminyl-peptide:amine gamma-glutamyl transferase activity,
TGase activity,
factor XIIIa,
fibrin stabilizing factor,
fibrinoligase activity,
glutaminylpeptide gamma-glutamyltransferase activity,
polyamine transglutaminase activity,
protein-glutamine gamma-glutamyltransferase activity,
protein-glutamine:amine gamma-glutamyltransferase,
tissue transglutaminase,
transglutaminase activity
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