Forms part of the peptidoglycan assembly pathway of Gram-positive bacteria grown in medium containing D-Asp.
| Predicate | Object |
|---|---|
| rdf:type | |
| rdfs:comment |
Forms part of the peptidoglycan assembly pathway of Gram-positive bacteria grown in medium containing D-Asp.,
Highly specific for D-aspartate, as L-aspartate, D-glutamate, D-alanine, D-iso-asparagine and D-malic acid are not substrates.,
Hybrid chains containing L-Ala-D-Asp, L-Ala-L-Ala-D-Asp or D-Asp-L-Ala are not formed.,
In Enterococcus faecium, the substrate D-aspartate is produced by EC 5.1.1.13.,
Normally, the side chains the acylate the 6-amino group of the L-lysine residue contain L-Ala-L-Ala but these amino acids are replaced by D-Asp when D-Asp is included in the medium.
|
| rdfs:subClassOf | |
| skos:broaderTransitive | |
| uniprot:name |
Asl(fm),
D-aspartate ligase,
D-aspartic acid-activating enzyme
|
| uniprot:activity |
ATP + D-aspartate + (beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala))(n) = (beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-6-N-(beta-D-Asp)-L-Lys-D-Ala-D-Ala))(n) + ADP + phosphate.
|