In organisms such as Methanosarcina barkeri that incorporate the modified amino acid pyrrolysine (Pyl) into certain methylamine methyltransferases, an unusual tRNA(Pyl), with a CUA anticodon, can be charged directly with pyrrolysine by this class II aminoacyl--tRNA ligase.
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| rdf:type | |
| rdfs:comment |
In organisms such as Methanosarcina barkeri that incorporate the modified amino acid pyrrolysine (Pyl) into certain methylamine methyltransferases, an unusual tRNA(Pyl), with a CUA anticodon, can be charged directly with pyrrolysine by this class II aminoacyl--tRNA ligase.,
Specific for pyrrolysine as substrate as it cannot be replaced by lysine or any of the other natural amino acids.
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| rdfs:subClassOf | |
| skos:broaderTransitive | |
| uniprot:name |
PylRS,
Pyrrolysine--tRNA(Pyl) ligase,
Pyrrolysyl-tRNA synthetase
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| uniprot:activity |
ATP + L-pyrrolysine + tRNA(Pyl) = AMP + diphosphate + L-pyrrolysyl-tRNA(Pyl).
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