This enzyme comprises a family of proteins involved in prokaryotic as well as eukaryotic protein synthesis.
| Predicate | Object |
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| rdf:type | |
| rdfs:comment |
EF-Tu and EF-1-alpha catalyze binding of aminoacyl-tRNA to the ribosomal A-site, while EF-G and EF-2 catalyze the translocation of peptidyl-tRNA from the A-site to the P-site.,
GTPase activity is also involved in polypeptide release from the ribosome with the aid of the pRFs and eRFs.,
In eukaryotes, it is eIF-2 (150 kDa) that binds GTP.,
In the elongation phase, the GTP-hydrolyzing proteins are the EF-Tu polypeptide of the prokaryotic transfer factor (43 kDa), the eukaryotic elongation factor EF-1-alpha (53 kDa), the prokaryotic EF-G (77 kDa), the eukaryotic EF-2 (70-110 kDa) and the signal recognition particle that play a role in endoplasmic reticulum protein synthesis (325 kDa).,
In the initiation factor complex, it is IF-2b (98 kDa) that binds GTP and subsequently hydrolyzes it in prokaryotes.,
This enzyme comprises a family of proteins involved in prokaryotic as well as eukaryotic protein synthesis.
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| rdfs:subClassOf | |
| skos:broaderTransitive | |
| uniprot:name |
Elongation factor (EF),
Initiation factor (IF),
Peptide-release factor (RF),
Peptide-release or termination factor,
Protein-synthesizing GTPase
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| uniprot:replaces | |
| uniprot:activity |
GTP + H(2)O = GDP + phosphate.
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