A membrane-bound glycoprotein found on the promastigote of various species of Leishmania protozoans.
| Predicate | Object |
|---|---|
| rdf:type | |
| rdfs:comment |
A membrane-bound glycoprotein found on the promastigote of various species of Leishmania protozoans.,
An acidic pH optimum is found with certain protein substrates.,
Belongs to peptidase family M8.,
Contains consensus sequence for a zinc binding site; Z-Tyr-Leu-NHOH is a strong inhibitor.,
The enzyme can activate its proenzyme by cleavage of the 100-Val-|-Val-101 bond.
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| rdfs:subClassOf | |
| skos:broaderTransitive | |
| uniprot:name |
Glycoprotein gp63,
Leishmanolysin,
Promastigote surface endopeptidase
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| uniprot:activity |
Preference for hydrophobic residues at P1 and P1' and basic residues at P2' and P3'. A model nonapeptide is cleaved at -Ala-Tyr-|-Leu-Lys-Lys-.
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| uniprot:cofactor |
Calcium,
Zinc
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