| Predicate | Object |
|---|---|
| rdf:type | |
| rdfs:comment |
Belongs to peptidase family A1.,
Suggested to be the major 'beta-secretase' responsible for the cleavage of the beta-amyloid precursor protein to form the amyloidogenic beta-peptide that is implicated in the pathology of Alzheimer's disease.
|
| rdfs:subClassOf | |
| skos:broaderTransitive | |
| uniprot:name |
BACE1,
Beta-secretase,
Beta-site APP-cleaving enzyme 1,
Beta-site Alzheimer's amyloid precursor protein cleaving enzyme 1,
Memapsin 2,
Membrane-associated aspartic protease 2
|
| uniprot:activity |
Broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-|-Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein.
|