| Predicate | Object |
|---|---|
| rdf:type | |
| rdfs:comment |
Apical activator of the extrinsic (death receptor) apoptosis pathway, triggered by death receptor ligation.,
Belongs to peptidase family C14.,
Caspase-8 is an initiator caspase, as are caspase-2 (EC 3.4.22.55), caspase-9 (EC 3.4.22.62) and caspase-10 (EC 3.4.22.63).,
Contains two tandem death effector domains (DEDs) in its N-terminal prodomain, which play a role in procaspase activation.,
Endogenous substrates for caspase-8 include procaspase-3, the pro-apoptotic Bcl-2 family member Bid, RIP, PAK2 and the caspase-8 activity modulator FLIP(L).,
Has a preference for Glu at P3 and prefers small residues, such as Gly, Ser and Ala at the P1' position.,
Has very broad P4 specificity, tolerating substrates with Asp, Val or Leu in this position.,
Linked to cell surface death receptors such as Fas.,
When Fas is aggregated by the Fas ligand, procaspase-8 is recruited to the death receptor where it is activated.
|
| rdfs:subClassOf | |
| skos:broaderTransitive | |
| uniprot:name |
Apoptotic cysteine protease,
Apoptotic protease Mch-5,
CAP4,
CASP-8,
Caspase-8,
FADD-homologous ICE/CED-3-like protease,
FADD-like ICE,
FLICE,
ICE-like apoptotic protease 5,
MACH,
MORT1-associated CED-3 homolog,
Mammalian Ced-3 homolog 5,
Mch5
|
| uniprot:activity |
Strict requirement for Asp at position P1 and has a preferred cleavage sequence of (Leu/Asp/Val)-Glu-Thr-Asp-|-(Gly/Ser/Ala).
|