| Predicate | Object |
|---|---|
| rdf:type | |
| rdfs:comment |
Belongs to peptidase family C14.,
Can also cleave and inactivate lamins, the intermediate filament scaffold proteins of the nuclear envelope, leading to nuclear fragementation in the final phases of apoptosis.,
Caspase-6 can cleave its prodomain to produce mature caspase-6, which directly activates caspase-8 (EC 3.4.22.61) and leads to cytochrome c release from the mitochondria; the release of cytochrome c, which is an essential component of the intrinsic apoptosis pathway.,
Caspase-6 is an effector/executioner caspase, as are caspase-3 (EC 3.4.22.56) and caspase-7 (EC 3.4.22.60).,
These caspases are responsible for the proteolysis of the majority of cellular polypeptides, (e.g. poly(ADP-ribose) polymerase (PARP)), which lead to the apoptotic phenotype.
|
| rdfs:subClassOf | |
| skos:broaderTransitive | |
| uniprot:name |
Apoptotic protease Mch-2,
CASP-6,
Caspase-6,
Mch2
|
| uniprot:activity |
Strict requirement for Asp at position P1 and has a preferred cleavage sequence of Val-Glu-His-Asp-|-.
|