Globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase

Globoside is a neutral glycosphingolipid in human erythrocytes and has blood-group-P-antigen activity.

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Predicate	Object
rdf:type	uniprot:Enzyme
rdfs:comment	Globoside is a neutral glycosphingolipid in human erythrocytes and has blood-group-P-antigen activity., Lactosylceramide, globoside and gangliosides GM3 and GD3 are not substrates., UDP-GalNAc is the only sugar donor that is used efficiently by the enzyme: UDP-Gal and UDP-GlcNAc result in very low enzyme activity.
rdfs:subClassOf	http://purl.uniprot.org/enzyme/2.4.1.-
skos:broaderTransitive	http://purl.uniprot.org/enzyme/2.4.1.-
uniprot:name	Beta-3GalNAc-T1, Galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase, Globoside synthase, Globoside synthetase, Globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase, Uridine diphosphoacetylgalactosamine-galactosylgalactosylglucosylceramide acetylgalactosaminyltransferase
uniprot:activity	UDP-N-acetyl-D-galactosamine + alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = UDP + N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide.
uniprot:cofactor	Manganese