An essential membrane enzyme, functioning at the central junction of glycolysis, respiration and phospholipid biosynthesis.
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| rdfs:comment |
An essential membrane enzyme, functioning at the central junction of glycolysis, respiration and phospholipid biosynthesis.,
In bacteria, the enzyme is localized to the cytoplasmic membrane, while in eukaryotes it is tightly bound to the outer surface of the inner mitochondrial membrane.,
In eukaryotes, this enzyme, together with the cytosolic enzyme EC 1.1.1.8 forms the glycerol-3-phosphate shuttle by which NADH produced in the cytosol, primarily from glycolysis, can be reoxidized to NAD(+) by the mitochondrial electron-transport chain.,
Insect flight muscle uses only CoQ(10) as the physiological quinone whereas hamster and rat mitochondria use mainly CoQ(9).,
The enzyme is activated by calcium.,
This shuttle plays a critical role in transferring reducing equivalents from cytosolic NADH into the mitochondrial matrix.
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| uniprot:name |
FAD-dependent glycerol-3-phosphate dehydrogenase,
Flavin-linked glycerol-3-phosphate dehydrogenase,
Glycerol-3-phosphate CoQ reductase,
Glycerol-3-phosphate dehydrogenase,
Glycerophosphate dehydrogenase,
L-glycerophosphate dehydrogenase,
sn-glycerol-3-phosphate dehydrogenase
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| uniprot:replaces | |
| uniprot:activity |
sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol.
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| uniprot:cofactor |
Flavin
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