We molecularly cloned a cDNA coding for a novel phosphotyrosine molecule with a 70 kDa molecular mass, named STAM (signal transducing adaptor molecule), which is tyrosine-phosphorylated rapidly after stimulation with various cytokines such as IL-2, IL-3, IL-4, IL-7, GM-CSF, EGF and PDGF. STAM contains an SH3 (Src-homology 3) domain and the ITAM (immunoreceptor tyrosine-based activation motif), suggesting that STAM acts as an adaptor molecule involved in signal transducing pathways from the cytokine receptors.
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| rdf:type | |
| rdfs:comment |
We molecularly cloned a cDNA coding for a novel phosphotyrosine molecule with a 70 kDa molecular mass, named STAM (signal transducing adaptor molecule), which is tyrosine-phosphorylated rapidly after stimulation with various cytokines such as IL-2, IL-3, IL-4, IL-7, GM-CSF, EGF and PDGF. STAM contains an SH3 (Src-homology 3) domain and the ITAM (immunoreceptor tyrosine-based activation motif), suggesting that STAM acts as an adaptor molecule involved in signal transducing pathways from the cytokine receptors.
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| skos:exactMatch | |
| uniprot:name |
Biochem. Biophys. Res. Commun.
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| uniprot:author |
Arita T.,
Asao H.,
Endo Y.,
Fujita T.,
Higuchi M.,
Kaneko K.,
Kuroda H.,
Munakata H.,
Sugamura K.,
Takeshita T.,
Tanaka N.
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| uniprot:date |
1996
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| uniprot:pages |
1035-1039
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| uniprot:title |
Cloning of a novel signal-transducing adaptor molecule containing an SH3 domain and ITAM.
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| uniprot:volume |
225
|
| dc-term:identifier |
doi:10.1006/bbrc.1996.1290
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