The venom of a fish-hunting cone snail (Conus geographus) contains a novel toxin, the "sleeper" peptide, which induces a sleep-like state in mice when injected intracerebrally. We demonstrate that this peptide contains 5 mol of gamma-carboxyglutamate (Gla) in 17 amino acids. The amino acid sequence of the sleeper peptide is Gly-Glu-Gla-Gla-Leu-Gln-Gla-Asn-Gln-Gla-Leu-Ile-Arg-Gla-Lys-Ser-Asn-NH2.
| Predicate | Object |
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| rdf:type | |
| rdfs:comment |
The venom of a fish-hunting cone snail (Conus geographus) contains a novel toxin, the "sleeper" peptide, which induces a sleep-like state in mice when injected intracerebrally. We demonstrate that this peptide contains 5 mol of gamma-carboxyglutamate (Gla) in 17 amino acids. The amino acid sequence of the sleeper peptide is Gly-Glu-Gla-Gla-Leu-Gln-Gla-Asn-Gln-Gla-Leu-Ile-Arg-Gla-Lys-Ser-Asn-NH2.
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| skos:exactMatch | |
| uniprot:name |
J. Biol. Chem.
|
| uniprot:author |
Cruz L.J.,
Gray W.R.,
McIntosh J.M.,
Olivera B.M.
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| uniprot:date |
1984
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| uniprot:pages |
14343-14346
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| uniprot:title |
Gamma-carboxyglutamate in a neuroactive toxin.
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| uniprot:volume |
259
|