The nucleotide sequence analysis of cloned cDNA for VIP precursor from rat cerebral cortex reveals that the precursor contains both rat VIP and PHI-27. The deduced primary structure of rat VIP is identical with human VIP. The amino acid sequence of rat PHI-27 differs by 4 amino acids from human PHM-27. When each VIP precursor is divided functionally into 6 domains, the amino acid sequence homology between rat and human precursors ranges from 69 to 100%. In contrast, any domain exhibits an essentially equal degree of nucleotide sequence homology.
| Predicate | Object |
|---|---|
| rdf:type | |
| rdfs:comment |
The nucleotide sequence analysis of cloned cDNA for VIP precursor from rat cerebral cortex reveals that the precursor contains both rat VIP and PHI-27. The deduced primary structure of rat VIP is identical with human VIP. The amino acid sequence of rat PHI-27 differs by 4 amino acids from human PHM-27. When each VIP precursor is divided functionally into 6 domains, the amino acid sequence homology between rat and human precursors ranges from 69 to 100%. In contrast, any domain exhibits an essentially equal degree of nucleotide sequence homology.
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| skos:exactMatch | |
| uniprot:name |
FEBS Lett.
|
| uniprot:author |
Hayakawa Y.,
Nishizawa M.,
Okamoto H.,
Yanaihara N.
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| uniprot:date |
1985
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| uniprot:pages |
55-59
|
| uniprot:title |
Nucleotide sequence divergence and functional constraint in VIP precursor mRNA evolution between human and rat.
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| uniprot:volume |
183
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| dc-term:identifier |
doi:10.1016/0014-5793(85)80953-4
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