Monkeypox virus (MPV) causes a human disease which resembles smallpox but with a lower person-to-person transmission rate. To determine the genetic relationship between the orthopoxviruses causing these two diseases, we sequenced the 197-kb genome of MPV isolated from a patient during a large human monkeypox outbreak in Zaire in 1996. The nucleotide sequence within the central region of the MPV genome, which encodes essential enzymes and structural proteins, was 96.3% identical with that of variola (smallpox) virus (VAR). In contrast, there were considerable differences between MPV and VAR in the regions encoding virulence and host-range factors near the ends of the genome. Our data indicate that MPV is not the direct ancestor of VAR and is unlikely to naturally acquire all properties of VAR.
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| rdfs:comment |
Monkeypox virus (MPV) causes a human disease which resembles smallpox but with a lower person-to-person transmission rate. To determine the genetic relationship between the orthopoxviruses causing these two diseases, we sequenced the 197-kb genome of MPV isolated from a patient during a large human monkeypox outbreak in Zaire in 1996. The nucleotide sequence within the central region of the MPV genome, which encodes essential enzymes and structural proteins, was 96.3% identical with that of variola (smallpox) virus (VAR). In contrast, there were considerable differences between MPV and VAR in the regions encoding virulence and host-range factors near the ends of the genome. Our data indicate that MPV is not the direct ancestor of VAR and is unlikely to naturally acquire all properties of VAR.
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| uniprot:name |
FEBS Lett.
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| uniprot:author |
Babkin I.V.,
Esposito J.J.,
Gutorov V.V.,
Jahrling P.B.,
Mikheev M.V.,
Moss B.,
Petrov N.A.,
Ryazankina O.I.,
Safronov P.F.,
Sandakhchiev L.S.,
Shchelkunov S.N.,
Sisler J.R.,
Totmenin A.V.,
Uvarova E.A.
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| uniprot:date |
2001
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| uniprot:pages |
66-70
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| uniprot:title |
Human monkeypox and smallpox viruses: genomic comparison.
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| uniprot:volume |
509
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| dc-term:identifier |
doi:10.1016/S0014-5793(01)03144-1
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