25E30A54A6ECD1B9158BB8BBFE8E2DB8576AAC99AF9A98AE9DC6F0541FC2CA735D51D243E5AB0BED5712129EF38C0D16

Contains 3 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases, including PTPN6/SHP-1, resulting in the dephosphorylation of the downstream protein kinases SYK and BTK.

Source:http://purl.uniprot.org/SHA-384/25E30A54A6ECD1B9158BB8BBFE8E2DB8576AAC99AF9A98AE9DC6F0541FC2CA735D51D243E5AB0BED5712129EF38C0D16

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Predicate	Object
rdf:type	uniprot:Domain_Annotation
rdfs:comment	Contains 3 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases, including PTPN6/SHP-1, resulting in the dephosphorylation of the downstream protein kinases SYK and BTK.