. "\"Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.\" [GOC:mah]" . . "intrinsic to membrane" . "Note that proteins intrinsic to membranes cannot be removed without disrupting the membrane, e.g. by detergent." . .