Source:http://linkedlifedata.com/resource/entrezgene/interaction/3117-156110
| Predicate | Object |
|---|---|
| rdf:type | |
| entrezgene:pubmed |
pubmed-article:11593029,
pubmed-article:12836198,
pubmed-article:12970439,
pubmed-article:15078178,
pubmed-article:15194762,
pubmed-article:16091223,
pubmed-article:16354571,
pubmed-article:16454711,
pubmed-article:19149577,
pubmed-article:19449444,
pubmed-article:19620308,
pubmed-article:19770068,
pubmed-article:21922073,
pubmed-article:22103833,
pubmed-article:22103834,
pubmed-article:22175768
|
| entrezgene:interactant | |
| entrezgene:geneRifText |
Expression of patient-derived HIV-1 nef alleles downregulates MHC-II cell surface expression in activated CD4+ T cells,
HIV-1 Nef expression inhibits MHC II presentation of viral antigens in infected antigen-presenting cells,
HIV-1 group N and group O Nef alleles only weakly downregulate CD4, CD28, and class I and II MHC molecules,
Nef-triggered MHCII endocytosis requires Rab5 activity and lyst function, whereas lysosomal trafficking of internalized MHCII molecules requires Rab7 activity
|
| entrezgene:keyphrase |
inhibits,
downregulates
|