Source:http://linkedlifedata.com/resource/entrezgene/interaction/27350-155459
| Predicate | Object |
|---|---|
| rdf:type | |
| entrezgene:pubmed |
pubmed-article:15809227,
pubmed-article:16414984,
pubmed-article:17967058,
pubmed-article:17977970,
pubmed-article:18304004,
pubmed-article:18419775,
pubmed-article:18577210,
pubmed-article:18806783,
pubmed-article:18846074,
pubmed-article:19088851,
pubmed-article:19109396,
pubmed-article:19535450,
pubmed-article:19581596,
pubmed-article:20012521,
pubmed-article:20174454,
pubmed-article:20926562,
pubmed-article:20943965,
pubmed-article:21279453,
pubmed-article:22205746,
pubmed-article:22379088
|
| entrezgene:interactant | |
| entrezgene:geneRifText |
A novel conserved 69YXXL72 motif in HIV-1 Vif regulates A3C expression in cells,
A potent small molecular compound VEC-5 protects APOBEC3G, APOBEC3F, and APOBEC3C from HIV-1 Vif-induced degradation and enhances A3G incorporation into HIV-1 virions by inhibiting the interaction between Vif and elongin C,
APOBEC3C restricts HIV-1 replication by causing G to A mutations in viral DNA replication intermediates; HIV-1 Vif binds to and destabilizes APOBEC3C,
Affinity Capture-Western; PCA,
Amino acid E289 in the EFLARH sequence of A3C is critical for HIV-1 Vif-mediated degradation,
CBF-beta-mediated increase of HIV-1 Vif steady-state levels results in decreased cellular levels of all Vif-sensitive APOBEC proteins (A3C, A3D, A3F, A3G, and A3H haplotype II),
HIV-1 Vif K22E and RH41/42AA mutants are able to suppress the anti-viral activity of A3C, but are ineffective in suppressing the anti-viral activity of A3G. K22, R41, and H42 residues are important for Vif-mediated degradation of A3G, but not A3C,
Small molecule RN-18 specifically inhibits HIV-1 Vif-mediated downregulation of APOBEC3C/F/G proteins by decreasing Vif protein levels when Vif interacts with these proteins,
Stress causes A3A, A3B, A3C, and A3F to co-localize efficiently with Vif(IIIB) and mRNA-PABP1 complexes in stress granules,
The LV portion of the Vif SLV/Ix4Yx9Y motif is required for optimal suppression of A3C or A3DE,
Vif(IIIB) induces A3A, A3B, and A3C emigration from the nucleus to the cytosol and thereby causes net increases in their cytosolic concentrations and anti-HIV-1 activities
|
| entrezgene:interactionSourc... |
BioGRID
|
| entrezgene:keyphrase |
downregulates,
interacts with,
co-localizes with,
relocalizes,
binds,
regulates,
degrades
|