Source:http://linkedlifedata.com/resource/entrezgene/hivinteraction/156110-7409
| Predicate | Object |
|---|---|
| rdf:type | |
| entrezgene:pubmed |
pubmed-article:10394361,
pubmed-article:11463741,
pubmed-article:11525746,
pubmed-article:12734410,
pubmed-article:12884293,
pubmed-article:14597672,
pubmed-article:16091223,
pubmed-article:16356860,
pubmed-article:16454711,
pubmed-article:17707624,
pubmed-article:18094167,
pubmed-article:18473783,
pubmed-article:19149577,
pubmed-article:21738584,
pubmed-article:22323535,
pubmed-article:22844345
|
| entrezgene:interactant | |
| entrezgene:geneRifText |
Nef-mediated microdomain recruitment of Vav1 is associated with the Nef-p21-activated kinase 2 (PAK2) signalosome. Nef residue F195 is identified as critical for Nef-mediated raft recruitment of Vav1,
The C-terminal SH3 domain of Vav binds to the PXXP motif in HIV-1 Nef and this interaction activates Vav and its downstream effectors, leading to morphological changes, cytoskeletal rearrangements, and the activation of the JNK/SAPK cascade,
The association of HIV-1 Nef with Vav1, Pak2, and Nck1 is greatly reduced in SLP76-deficient T cells,
The interaction of HIV-1 Nef with Vav is detected by pull-down assays; mutations in the Nef PXXP motif maintain some residual binding capacity to Vav
|
| entrezgene:keyphrase |
binds,
associates with,
recruits
|