. . . . . . . "Assays with phage-displayed Nef from HIV-1 NL4-3 have been used to identify a series of guanidine alkaloid-based inhibitors of Nef interactions with p53, actin, and p56(lck)" . "HIV-1 Nef binds directly to tumor suppressor protein p53; an N-terminal 57-residue fragment of Nef (Nef 1-57) contains the p53-binding domain" . "interacts with" . "binds" .