Source:http://linkedlifedata.com/resource/entrezgene/hivinteraction/156110-7124
| Predicate | Object |
|---|---|
| rdf:type | |
| entrezgene:pubmed |
pubmed-article:10388525,
pubmed-article:10415019,
pubmed-article:11000208,
pubmed-article:11153078,
pubmed-article:12370346,
pubmed-article:12504564,
pubmed-article:12574335,
pubmed-article:15576488,
pubmed-article:16091223,
pubmed-article:16445909,
pubmed-article:16454711,
pubmed-article:17077296,
pubmed-article:17086054,
pubmed-article:19455469,
pubmed-article:20068037,
pubmed-article:20299515,
pubmed-article:20380698,
pubmed-article:21668366,
pubmed-article:21858117,
pubmed-article:21886773,
pubmed-article:21922073,
pubmed-article:22395607,
pubmed-article:22407921
|
| entrezgene:interactant | |
| entrezgene:geneRifText |
Both the myristoylation site and the acidic cluster in HIV-1 Nef are required for the activation of NF-kappaB, which induces upregulation of TNFalpha and IL6 expression,
Expression of HIV-1 Nef in a CD4+ human T-cell hybridoma enhances the surface levels of the membrane-bound cytokines tumor necrosis factor (TNF) and LIGHT; the enhancement of TNF and LIGHT depends on the presence of a functional dileucine motif in Nef,
HIV-1 Nef and ALK show similar effects by increasing different cytokines/chemokines, such as IL-1beta, TNF-alpha, and RANTES, that may be relevant for HAD pathogenesis,
HIV-1 Nef expression by immature human and macaque dendritic cells (DCs) upregulates IL-6, IL-12, TNF-alpha, CXCL8, CCL3, and CCL4 release, but without upregulating co-stimulatory and other molecules characteristic of mature DCs,
HIV-1 Nef impairs the recruitment of TNF-alpha-positive compartments at the site of phagocytosis,
HIV-1 Nef increases the level of tumor necrosis factor-alpha release from primary human-monocyte-derived macrophages (MDM) infected with HIV-1,
HIV-1 Nef inhibits IFN-gamma-induced apoptosis and upregulates TNF-alpha, IL-6 and MIP-3a production by Caco-2 cells while downregulating IL-10 production,
HIV-1 Nef significantly increases TNF-a release from Nef-treated homeostatic or inflamed mucosal cell lines. Nef abrogates the IFN-gamma-induced modulation of TNF-alpha secretion in these cells,
HIV-1 nef gene expression in human glial cells inhibits tumor necrosis factor alpha-induced apoptosis and promotes cell proliferation through the activation of MAPK and JNK,
Intracisternal HIV-1 Nef injection upregulates levels of IL-6, TNF-alpha, and IFN-gamma in rat cerebrospinal fluid,
Mycobacterium tuberculosis-induced TNF-alpha production depends upon the Ets, Egr, Sp1, CRE or AP1 binding sites on the TNF-alpha promoter, whereas Nef-mediated promoter activation depends only on the CRE and AP1 binding sites,
Nef inhibits ASK1/p38MAPK-dependent Mycobacterium tuberculosis-induced TNF-alpha production by inhibiting binding of ATF2 to the TNF-alpha promoter,
Nef-induced expression of TNF-alpha is observed in rat hippocampus grafted with Nef-transduced macrophages,
Stimulation of CD8+ T cells with HIV-1 Nef peptides upregulates perforin and TNF-a expression,
The activating effect of exogenous HIV-1 Nef on PBMC proliferation and on monocyte-derived macrophages is associated with an upregulation of TNF-alpha and IL-6 production,
The presence of recombinant HIV-1 Nef and ethanol upregulates the level of tumor necrosis factor alpha (TNF-alpha) production in primary human brain micro vascular endothelial cells
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| entrezgene:keyphrase |
inhibits,
upregulates,
disrupts,
activates
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