Source:http://linkedlifedata.com/resource/entrezgene/hivinteraction/155971-1232
| Predicate | Object |
|---|---|
| rdf:type | |
| entrezgene:pubmed |
pubmed-article:10590105,
pubmed-article:10877489,
pubmed-article:11115360,
pubmed-article:15053339,
pubmed-article:15194768,
pubmed-article:15992849,
pubmed-article:16470129,
pubmed-article:16631222,
pubmed-article:16712896,
pubmed-article:16904155,
pubmed-article:17041228,
pubmed-article:19553323,
pubmed-article:20921899,
pubmed-article:22086059,
pubmed-article:22842622,
pubmed-article:8674119,
pubmed-article:9359702,
pubmed-article:9636210,
pubmed-article:9653051,
pubmed-article:9736741
|
| entrezgene:interactant | |
| entrezgene:geneRifText |
Amino acid N356 in conserved region 3 of HIV-1 gp120 and amino acids R440 and N448 in conserved region 4 of gp120 are three amino-acid determinants for CCR3 use as a coreceptor for HIV-1 entry into cells,
HIV-1 gp120 utilization of CCR3 as a coreceptor facilitates infection by a more restricted subset of primary viruses, and binding of the CCR3 ligand, eotaxin, inhibits infection by these isolates,
HIV-1 isolates showing CCR3 tropism are particularly efficient in using CMKLR1/ChemR23 as a co-receptor; some HIV-2 and SIV isolates also use CMKLR1/ChemR23,
Macrophage-tropic HIV-1 can use CCR2b, and to a lesser extent CCR3, STRL33, and APJ, to infect cells; the V1/2 region of HIV-1 gp120 plays a more important role in governing the use of CCR2b, CCR3, STRL33, and APJ than for CXCR4,
The coreceptor-binding site in HIV-1 gp120 is centered around an anti-parallel beta-sheet structure bridging sheet domain; mutations in and adjacent to this domain affect the use of coreceptors CCR3 and CCR8 by gp120 for virus entry,
Utilization of CCR3 and CCR5 as coreceptors of HIV-1 binding/fusion depends upon the sequence of the third variable (V3) region of the HIV-1 gp120 exterior envelope glycoprotein
|
| entrezgene:keyphrase |
binds
|