Source:http://linkedlifedata.com/resource/entrezgene/hivinteraction/155871-6347
| Predicate | Object |
|---|---|
| rdf:type | |
| entrezgene:pubmed |
pubmed-article:10068657,
pubmed-article:10453044,
pubmed-article:10644332,
pubmed-article:10751368,
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pubmed-article:11154208,
pubmed-article:12473373,
pubmed-article:12485413,
pubmed-article:12753088,
pubmed-article:12758167,
pubmed-article:14550782,
pubmed-article:15194470,
pubmed-article:15630704,
pubmed-article:16206161,
pubmed-article:16697675,
pubmed-article:16750572,
pubmed-article:17376903,
pubmed-article:18074388,
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pubmed-article:22487967,
pubmed-article:9501225,
pubmed-article:9789057,
pubmed-article:9792375
|
| entrezgene:interactant | |
| entrezgene:geneRifText |
Astrocyte cultures treated with morphine and Tat show exaggerated increases in chemokine release, including monocyte chemoattractant protein-1 (MCP-1), RANTES, and IL-6,
CDK9 is involved in Tat-induced MCP-1/CCL2 gene expression in human astrocytes,
HIV-1 Tat downregulates the expression of adiponectin protein and upregulates the expression of IL-6, IL-8, and MCP-1 proteins in human SGBS preadipocytes,
HIV-1 Tat is a competitive inhibitor of MCP-1 binding to CCR2,
HIV-1 Tat upregulates MCP-1 expression, an effect that may contribute to the pathogenesis of Tat associated with AIDS dementia,
MCP-1 and RANTES have been shown to inhibit Tat-induced apoptosis of mixed cultures of human neurons and astrocytes,
Over-expression of PPARalpha or PPARgamma attenuates Tat-induced up-regulation of inflammatory mediators, such as interleukin (IL)-1beta, tumor necrosis factor-alpha, CCL2, and E-selectin,
Tat-mediated upregulation of MCP-1 transcription is stimulated by Smad-3 and decreased by Smad-4,
The C-terminal MH2 domain of Smad3 can decrease the levels of HIV-1 Tat-induced activation of MCP-1 in astrocytic cells,
The endogenous PPARgamma ligand 15d-PGJ2 inhibits HIV-1 Tat-induced MCP-1 production in human microglia-like cells,
Upregulation of MCP-1 by HIV-1 Tat in astrocytes is inhibited by the MEK1/2 inhibitor UO126, indicating a role for MEK1/2 in Tat-mediated chemokine induction,
Upregulation of MCP-1 by HIV-1 Tat is mediated at the transcriptional level and is regulated, at least in part, by NF-kappa B, AP1, Sp1, protein kinase C and PI3 kinase
|
| entrezgene:keyphrase |
inhibits,
inhibited by,
upregulates,
activates
|