Source:http://linkedlifedata.com/resource/entrezgene/hivinteraction/155871-3558
| Predicate | Object |
|---|---|
| rdf:type | |
| entrezgene:pubmed |
pubmed-article:10207088,
pubmed-article:11114167,
pubmed-article:11254713,
pubmed-article:11385624,
pubmed-article:11689614,
pubmed-article:1394441,
pubmed-article:17604883,
pubmed-article:18539368,
pubmed-article:21085635,
pubmed-article:7695626,
pubmed-article:7734194,
pubmed-article:7983746,
pubmed-article:7999066,
pubmed-article:8095514,
pubmed-article:8207793,
pubmed-article:9045614
|
| entrezgene:interactant | |
| entrezgene:geneRifText |
Four mutations (C27S, K51T, R55L, and G79A) on HIV-1 Tat result in the loss of the deleterious effects of Tat on the expression of MHC I, IL-2, and CD25 genes compared with wild-type Tat in Jurkat cells,
HIV-1 Tat downregulates IL-2 expression in Jurkat T-cells stably transfected with Tat, H9 T-cells, as well as other T-cells, through an effect on the rel/AP1 complex and IL-2 promoter, resulting in functional unresponsiveness in T-cells,
HIV-1 Tat downregulates IL-2 expression in T-cells by inhibiting CD26 which interferes with the delivery or amplification of a signal necessary for IL-2 production,
HIV-1 Tat upregulates IL-2 expression in activated T-cells and Jurkat T-cells through activation of the IL-2 promoter, an effect involving NF-kappa B, NFAT, and cyclic nucleoside phosphodiesterase 4,
Treatment of T lymphocytes with IL-2, IL-6 and TNFalpha increases CDK9 and cyclin T1 protein levels, suggesting a mechanism for activation of HIV-1 Tat function and reactivation of HIV-1 in CD4+ T lymphocytes harboring a latent provirus
|
| entrezgene:keyphrase |
downregulates,
upregulates,
activated by
|