Source:http://linkedlifedata.com/resource/entrezgene/hivinteraction/155871-10614
| Predicate | Object |
|---|---|
| rdf:type | |
| entrezgene:pubmed |
pubmed-article:12832472,
pubmed-article:15855166,
pubmed-article:15992410,
pubmed-article:17314519,
pubmed-article:17341462,
pubmed-article:17576689,
pubmed-article:18281698,
pubmed-article:18483487,
pubmed-article:18655042,
pubmed-article:18773076,
pubmed-article:19275730,
pubmed-article:19387490,
pubmed-article:19716452,
pubmed-article:20562857,
pubmed-article:20683478,
pubmed-article:20808803,
pubmed-article:20976203,
pubmed-article:21360054,
pubmed-article:22100159,
pubmed-article:22377309,
pubmed-article:22422068
|
| entrezgene:interactant | |
| entrezgene:geneRifText |
A La-related protein, LARP7, is associated with P-TEFb, HEXIM1/2, MEPCE, and 7SK RNA in a large stable complex form. Knockdown of LARP7 decreases the steady-state level of 7SK, but increases free P-TEFb and enhances Tat-mediated transcription,
CDK11 depletion reduces protein expression of CDK9 and HEXIM1 and Tat transactivation of HIV-1 provirus,
HIV-1 Tat competes with HEXIM1 for binding to 7SK RNA and inhibits the formation of the P-TEFb-HEXIM1-7SK complex. Tat binds to nucleotides 10-48 of 7SK RNA,
HIV-1 Tat competes with Hexim1 (residues 255-359) for cyclin T1 binding, thus releasing P-TEFb from the inactive complex to stimulate the transcription of HIV-1 gene expression,
HIV-1 Tat directly interacts with human 7SK snRNA in living cells. The 5' hairpin of human 7SK snRNA carries a conserved Tat-binding element and two HEXIM1-binding sites. Tat competes with HEXIM1 for 7SK snRNA binding,
HIV-1 Tat displaces HEXIM1 from Cyclin T1 in the context of the native 7SK snRNP by interacting with the Cyclin T1-binding domain (amino acid 255-359) of HEXIM1,
HIV-1 Tat transactivation is effectively inhibited by co-expression of HEXIM1 or its paralog HEXIM2; HEXIM1 expression specifically represses transcription mediated by the direct activation of P-TEFb through Tat recruitment of CycT1,
HIV-1 Tat-mediated release of P-TEFb from the 7SK sn RNP results in a conformational change in 7SK RNA and release of HEXIM1 from the complex,
MAQ1 complexes with 7SK RNA and cyclin T1 and competes with the binding of Tat to cyclin T1, suggesting the TAR RNA/Tat lentivirus system has evolved to subvert the cellular 7SK RNA/MAQ1 system,
TAR binds Tat and P-TEFb as it emerges on the nascent transcript, competitively displacing the inhibitory 7SK snRNP (HEXIM1 and LARP7) and activating the P-TEFb kinase
|
| entrezgene:keyphrase |
interacts with,
inhibited by,
induces release of,
competes with,
displaces
|