Source:http://linkedlifedata.com/resource/entrezgene/hivinteraction/155807-545
| Predicate | Object |
|---|---|
| rdf:type | |
| entrezgene:pubmed |
pubmed-article:12738771,
pubmed-article:15485898,
pubmed-article:15650754,
pubmed-article:16306615,
pubmed-article:16354571,
pubmed-article:16956949,
pubmed-article:17140287,
pubmed-article:17210576,
pubmed-article:18514189,
pubmed-article:19275579,
pubmed-article:19275588,
pubmed-article:19798433,
pubmed-article:20008788,
pubmed-article:20012529,
pubmed-article:20347598,
pubmed-article:21874023,
pubmed-article:21994772
|
| entrezgene:interactant | |
| entrezgene:geneRifText |
ATR-induced phosphorylation of Chk1-Ser(345) requires PP2A only when Vpr activates ATR,
Depletion of A-alpha and C-beta subunits of PP2A reduces Vpr-induced G2 arrest to the same extent as depletion of ATM and Rad3-related (ATR),
HIV-1 Vpr activates ATR, resulting in phosphorylation of Chk1 and activation of the ATR-mediated DNA damage response,
HIV-1 Vpr induces phosphorylation of BRCA1 at serine 1423 in an ATR-dependent manner,
HIV-1 Vpr induces phosphorylation of replication protein A (RPA32) at serine 4 and 8 in an ATR-dependent manner,
HIV-1 Vpr-induced apoptosis is mediated via Bax, downstream of ATR activation,
Upregulation of NKG2D ligands is dependent on HIV-1 Vpr-mediated activation of the ATR DNA damage/stress pathway, which requires the recruitment of the Cul4/DDB1/DCAF1 E3 ubiquitin ligase complex
|
| entrezgene:keyphrase |
interacts with,
activates
|