Source:http://linkedlifedata.com/resource/entrezgene/hivinteraction/155030-4734
| Predicate | Object |
|---|---|
| rdf:type | |
| entrezgene:pubmed |
pubmed-article:11087859,
pubmed-article:11087860,
pubmed-article:11112487,
pubmed-article:11991975,
pubmed-article:12610113,
pubmed-article:19020832,
pubmed-article:19143627,
pubmed-article:20519395,
pubmed-article:21666754,
pubmed-article:22004035,
pubmed-article:22761998,
pubmed-article:22762019,
pubmed-article:9525617
|
| entrezgene:interactant | |
| entrezgene:geneRifText |
Nedd4 is one possible ubiquitin ligase implicated to interact with the L domain of HIV-1 p6-Gag resulting in monoubiquitination of p6,
Nedd4-1 facilitation of HIV-1 PTAP(-) release requires basic residues in Gag/NC,
Overexpression of Nedd4-1 rescues the HIV-1 PTAP- mutant budding defects and the ubiquitin ligase activity of Nedd4-1 and the LYPXnL motif of Gag/p6 are required for the Nedd4-1-mediated rescue,
The L domain (P(T/S)APP; amino acids 7-11) of HIV-1 p6-Gag interacts with a ubiquitin ligase complex resulting in the monoubiquitination of p6,
The leucine residues (211LYPL214 motif) within the C2 domain of Nedd4-1 mediate binding to Gag and play a critical role in Nedd4-1-mediated rescue of HIV-1 PTAP(-),
Ubiquitination of HIV-1 p6-Gag may be important for proper virus release from cells
|
| entrezgene:keyphrase |
interacts with,
binds,
ubiquitinated by
|